Carbohydrate-restricted diets reduce hepatic fat, cardiometabolic risk factors, according to new study


A study published in Cell Metabolism examined how a carbohydrate-restricted diet prevented fatty liver disease.

  • Researchers from Sweden looked at the impact of restricting carbohydrate intake on non-alcoholic fatty liver disease (NAFLD).
  • In the study, they put 10 participants who were both obese and had high liver fat on an isocaloric, low-carbohydrate diet with increased protein content.
  • They put together clinical and large data analysis to identify the subsequent changes in metabolism and gut bacteria.
  • With this, they determined why the study participants displayed rapid and great reductions of liver fat and other cardiometabolic risk factors, together with marked reductions in the synthesis of hepatic fat.
  • Results showed that the metabolism of dangerous hepatic lipids was greatly linked to a rapid increase in B vitamins and the bacteria that make folic acid.
  • Moreover, they saw a reduction in the expression of genes that play a role in the synthesis of fatty acid.
  • They also observed an increase in the expression of genes that contribute to folate-mediated one-carbon metabolism and fatty acid oxidation.
  • The researchers revealed that the diet elicited rapid and dramatic reductions of liver fat and other cardiometabolic risk factors. The diet also revealed formerly unknown underlying molecular mechanisms.
  • However, they also noted that diets are complicated and that one specific type of diet may not be suitable for everyone.

In conclusion, the findings of the study indicated that restricting carbohydrates in a diet can be an effective treatment option for severe health problems such as non-alcoholic fatty liver disease.

For the full text of the study, go to this link.

Journal Reference:

Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, et al. AN INTEGRATED UNDERSTANDING OF THE RAPID METABOLIC BENEFITS OF A CARBOHYDRATE-RESTRICTED DIET ON HEPATIC STEATOSIS IN HUMANS. Cell Metabolism. 2018;27(3):559–571. DOI: 10.1016/j.cmet.2018.01.005



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