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Dihydrocapsiate supplementation found to improve glucose tolerance, hepatic steatosis in high-fat diet-induced gut alterations


Researchers from India’s National Agri-Food Biotechnology Institute (NABI), Panjab University, and National Institute of Pharmaceutical Education and Research (NIPER) looked at the effects of dihydrocapsiate against metabolic disorders. The results of their study were published in the journal Nutrition Research.

  • Dihydrocapsiate is a compound that belongs to the capsinoid family.
  • Capsinoids are capsaicin analogs found in non-pungent peppers. They increase whole body energy expenditure.
  • In the study, the researchers hypothesized that dihydrocapsiate might ameliorate high-fat diet-induced metabolic disorders in a manner similar to capsaicin.
  • To test this hypothesis, they gave mice on a high-fat diet dihydrocapsiate (2 or 10 milligrams per kilogram (mg/kg) body weight) for 12 weeks.
  • The researchers reported that dihydrocapsiate modestly reduced weight gain caused by consumption of a high-fat diet.
  • It also significantly inhibited hyperglyceridemia and hyperinsulinemia and improved glucose tolerance.
  • In addition, dihydrocapsiate significantly suppressed lipid accumulation in white adipose tissue and brown adipose tissue by targeting genes involved in energy expenditure and mitochondrial biogenesis, respectively.
  • It also improved gut morphology and altered gut microbial composition.
  • These results suggested that dihydrocapsiate treatment can improve glucose tolerance, prevent obesity and fatty liver disease, and improve high-fat diet-induced gut alteration.

The researchers concluded that dihydrocapsiate can be used as a potential food ingredient for the dietary management of high-fat diet-induced metabolic changes.

Read more studies on food supplements that improve metabolic health by visiting FightObesity.news.

Journal Reference:

Baboota RK, Khare P, Mangal P, Singh DP, Bhutani KK, Kondepudi KK, Kaur J, Bishnoi M. DIHYDROCAPSIATE SUPPLEMENTATION PREVENTED HIGH-FAT DIET–INDUCED ADIPOSITY, HEPATIC STEATOSIS, GLUCOSE INTOLERANCE, AND GUT MORPHOLOGICAL ALTERATIONS IN MICE. Nutrition Research. March 2018;51:40-56. DOI: 10.1016/j.nutres.2017.11.006



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